The Children's Hospital of Philadelphia receives Grand Challenges Explorations funding

Public release date: 7-Nov-2011
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Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia

Research team is investigating novel drug approach for HIV

The Children's Hospital of Philadelphia announced today that it will receive funding through Grand Challenges Explorations, an initiative created by the Bill & Melinda Gates Foundation that enables researchers worldwide to test unorthodox ideas that address persistent health and development challenges.

Terri Finkel, M.D., Ph.D., chief of Rheumatology at Children's Hospital and Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania, will pursue an innovative global health research project, titled "Use of a BET Antagonist to Control and Cure HIV Infection."

Grand Challenges Explorations funds scientists and researchers worldwide to explore ideas that can break the mold in how we solve persistent global health and development challenges. Dr. Finkel's project is one of 110 Grand Challenges Explorations grants announced today.

"We believe in the power of innovationthat a single bold idea can pioneer solutions to our greatest health and development challenges," said Chris Wilson, Director of Global Health Discovery for the Bill & Melinda Gates Foundation. "Grand Challenges Explorations seeks to identify and fund these new ideas wherever they come from, allowing scientists, innovators and entrepreneurs to pursue the kinds of creative ideas and novel approaches that could help to accelerate the end of polio, cure HIV infection or improve sanitation."

Projects that are receiving funding show promise in tackling priority global health issues where solutions do not yet exist. This includes finding effective methods to eliminate or control infectious diseases such as polio and HIV as well as discovering new sanitation technologies.

To learn more about Grand Challenges Explorations, visit www.grandchallenges.org.

Dr. Finkel and her research team will study the potential of drugs called synthetic BET (bromodomain extra terminal) family protein antagonists to control HIV infection and latency. Current HIV drugs reduce the disease-causing virus to undetectable levels, but the virus goes into a dormant state called latency, from which it can make a resurgence if a patient stops taking medication. Previous studies by Dr. Finkel and other scientists have suggested that BET antagonists may flush HIV out of its hiding places where it can be destroyed by other antiretroviral drugs.

Dr. Finkel's chief collaborator in this project is Gerd A. Blobel, M.D., Ph.D., holder of the Frank E. Weise III Endowed Chair in Pediatric Hematology at The Children's Hospital of Philadelphia, who has focused on the biological activities of BET family proteins. In the first part of the project, Drs. Finkel and Blobel will investigate the effectiveness of BET antagonists against HIV in cell cultures. If these results are encouraging, the project will progress to clinical trials in patients with HIV. Because this class of drugs will soon be tested in humans as treatments for other diseases, appropriate BET antagonists are expected to be freely available for HIV clinical trials.

###

About Grand Challenges Explorations

Grand Challenges Explorations is a US$100 million initiative funded by the Bill & Melinda Gates Foundation. Launched in 2008, Grand Challenge Explorations grants have already been awarded to nearly 500 researchers from over 40 countries. The grant program is open to anyone from any discipline and from any organization. The initiative uses an agile, accelerated grant-making process with short, two-page online applications and no preliminary data required. Initial grants of $100,000 are awarded two times a year. Successful projects have an opportunity to receive a follow-on grant of up to US$1 million.

About The Children's Hospital of Philadelphia

The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 516-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 7-Nov-2011
[ | E-mail | Share ]

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia

Research team is investigating novel drug approach for HIV

The Children's Hospital of Philadelphia announced today that it will receive funding through Grand Challenges Explorations, an initiative created by the Bill & Melinda Gates Foundation that enables researchers worldwide to test unorthodox ideas that address persistent health and development challenges.

Terri Finkel, M.D., Ph.D., chief of Rheumatology at Children's Hospital and Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania, will pursue an innovative global health research project, titled "Use of a BET Antagonist to Control and Cure HIV Infection."

Grand Challenges Explorations funds scientists and researchers worldwide to explore ideas that can break the mold in how we solve persistent global health and development challenges. Dr. Finkel's project is one of 110 Grand Challenges Explorations grants announced today.

"We believe in the power of innovationthat a single bold idea can pioneer solutions to our greatest health and development challenges," said Chris Wilson, Director of Global Health Discovery for the Bill & Melinda Gates Foundation. "Grand Challenges Explorations seeks to identify and fund these new ideas wherever they come from, allowing scientists, innovators and entrepreneurs to pursue the kinds of creative ideas and novel approaches that could help to accelerate the end of polio, cure HIV infection or improve sanitation."

Projects that are receiving funding show promise in tackling priority global health issues where solutions do not yet exist. This includes finding effective methods to eliminate or control infectious diseases such as polio and HIV as well as discovering new sanitation technologies.

To learn more about Grand Challenges Explorations, visit www.grandchallenges.org.

Dr. Finkel and her research team will study the potential of drugs called synthetic BET (bromodomain extra terminal) family protein antagonists to control HIV infection and latency. Current HIV drugs reduce the disease-causing virus to undetectable levels, but the virus goes into a dormant state called latency, from which it can make a resurgence if a patient stops taking medication. Previous studies by Dr. Finkel and other scientists have suggested that BET antagonists may flush HIV out of its hiding places where it can be destroyed by other antiretroviral drugs.

Dr. Finkel's chief collaborator in this project is Gerd A. Blobel, M.D., Ph.D., holder of the Frank E. Weise III Endowed Chair in Pediatric Hematology at The Children's Hospital of Philadelphia, who has focused on the biological activities of BET family proteins. In the first part of the project, Drs. Finkel and Blobel will investigate the effectiveness of BET antagonists against HIV in cell cultures. If these results are encouraging, the project will progress to clinical trials in patients with HIV. Because this class of drugs will soon be tested in humans as treatments for other diseases, appropriate BET antagonists are expected to be freely available for HIV clinical trials.

###

About Grand Challenges Explorations

Grand Challenges Explorations is a US$100 million initiative funded by the Bill & Melinda Gates Foundation. Launched in 2008, Grand Challenge Explorations grants have already been awarded to nearly 500 researchers from over 40 countries. The grant program is open to anyone from any discipline and from any organization. The initiative uses an agile, accelerated grant-making process with short, two-page online applications and no preliminary data required. Initial grants of $100,000 are awarded two times a year. Successful projects have an opportunity to receive a follow-on grant of up to US$1 million.

About The Children's Hospital of Philadelphia

The Children's Hospital of Philadelphia was founded in 1855 as the nation's first pediatric hospital. Through its long-standing commitment to providing exceptional patient care, training new generations of pediatric healthcare professionals and pioneering major research initiatives, Children's Hospital has fostered many discoveries that have benefited children worldwide. Its pediatric research program is among the largest in the country, ranking third in National Institutes of Health funding. In addition, its unique family-centered care and public service programs have brought the 516-bed hospital recognition as a leading advocate for children and adolescents. For more information, visit http://www.chop.edu.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2011-11/chop-tch110711.php

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Men prefer football to finance | Bankrate.com

Fifty-eight percent of U.S. men spend more time each week watching sports than they spend working on their personal finances, including their investments, according to a new?national survey of 500 men conducted by TNS on behalf of ING Direct, an online bank, and Men's Health magazine.

However, there's still room for finances. ING Direct CEO Arkadi Kuhlmann said in a statement that a surprisingly large number of men surveyed were saving for retirement, paying off mortgages and watching their finances -- activities that happened less frequently five years ago.

"Being financially fit and responsible is something all consumers should strive for, and these findings prove that people see the value in being in control of their money and future," Kuhlmann said.

Other findings:

• 69 percent of men said they had more than six months' living expenses in an emergency fund.
• 31 percent had less than six months' expenses in liquid savings.
• 56 percent of men who owned a home said they were current on their payments and had some equity.
• 35 percent who owned a home said they had no mortgage and owned it outright.
• 51 percent of men said they always or usually paid their monthly credit card balances in full.
• 44 percent said they had a net worth of at least $100,000.
• 40 percent said they spend less than $49 each week on drinks, dining out, playing pool and similar activities.
• 11 percent said they spend $100 to $199 each week on such entertainments.

The survey was taken by telephone and online March 30 through April 3, 2011.

No word yet on the responses of the 500 women who were also surveyed.

Follow me on Twitter: @marciegeff

Source: http://www.bankrate.com/financing/banking/men-prefer-football-to-finance/

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Wayne State creating computer-based drug intervention for at-risk post-partum women

Public release date: 2-Nov-2011
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Contact: Julie O'Connor
julie.oconnor@gmail.com
313-577-8845
Wayne State University - Office of the Vice President for Research

DETROIT A team of researchers at Wayne State University's Parent Health Lab in the School of Medicine have developed a novel indirect screener that identifies women at risk for drug use by evaluating correlates of illicit drug use rather than drug use itself. In phase I testing, this new screener proved to be more sensitive than any alternative approach at detecting recent drug use. The team of researchers also developed a brief, computer-delivered intervention for behavioral change motivation that does not presume drug use.

Now, with a new $1.7 million grant from the National Institute on Drug Abuse of the National Institutes of Health, Steven Ondersma, Ph.D., associate professor in the Department of Psychiatry and Behavioral Neurosciences in WSU's School of Medicine and the Merrill-Palmer Skillman Institute, is leading a team of researchers to continue development and use of the screener, known as the Wayne Indirect Drug Use Screener (WIDUS). He and his team will also begin a formal trial with 500 at-risk women at Hutzel Hospital to evaluate the efficacy of a unique computer-delivered intervention that intends to motivate women to quit or reduce drug use without presuming that drug use is present.

According to Ondersma, many women who use drugs during or after pregnancy are hesitant to disclose that use for good reason. "This study could identify and help at-risk women, regardless of their comfort with disclosing drug use," said Ondersma.

In addition, Ondersma's use of a wholly computer-delivered model will help to make this a logistically feasible, replicable and low-cost approach that is far-reaching, ultimately having a widespread impact on providing brief interventions to at-risk post-partum women. If successful, this approach will also have a dual benefit through its indirect effects on at-risk children, including improving safety and stability, as well as behavior, health and school readiness.

"If we are successful, this new approach could give health care systems the ability to help far more at-risk women than was previously possible," said Ondersma.

###

Wayne State University is one of the nation's pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit http://www.research.wayne.edu.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-Nov-2011
[ | E-mail | Share ]

Contact: Julie O'Connor
julie.oconnor@gmail.com
313-577-8845
Wayne State University - Office of the Vice President for Research

DETROIT A team of researchers at Wayne State University's Parent Health Lab in the School of Medicine have developed a novel indirect screener that identifies women at risk for drug use by evaluating correlates of illicit drug use rather than drug use itself. In phase I testing, this new screener proved to be more sensitive than any alternative approach at detecting recent drug use. The team of researchers also developed a brief, computer-delivered intervention for behavioral change motivation that does not presume drug use.

Now, with a new $1.7 million grant from the National Institute on Drug Abuse of the National Institutes of Health, Steven Ondersma, Ph.D., associate professor in the Department of Psychiatry and Behavioral Neurosciences in WSU's School of Medicine and the Merrill-Palmer Skillman Institute, is leading a team of researchers to continue development and use of the screener, known as the Wayne Indirect Drug Use Screener (WIDUS). He and his team will also begin a formal trial with 500 at-risk women at Hutzel Hospital to evaluate the efficacy of a unique computer-delivered intervention that intends to motivate women to quit or reduce drug use without presuming that drug use is present.

According to Ondersma, many women who use drugs during or after pregnancy are hesitant to disclose that use for good reason. "This study could identify and help at-risk women, regardless of their comfort with disclosing drug use," said Ondersma.

In addition, Ondersma's use of a wholly computer-delivered model will help to make this a logistically feasible, replicable and low-cost approach that is far-reaching, ultimately having a widespread impact on providing brief interventions to at-risk post-partum women. If successful, this approach will also have a dual benefit through its indirect effects on at-risk children, including improving safety and stability, as well as behavior, health and school readiness.

"If we are successful, this new approach could give health care systems the ability to help far more at-risk women than was previously possible," said Ondersma.

###

Wayne State University is one of the nation's pre-eminent public research universities in an urban setting. Through its multidisciplinary approach to research and education, and its ongoing collaboration with government, industry and other institutions, the university seeks to enhance economic growth and improve the quality of life in the city of Detroit, state of Michigan and throughout the world. For more information about research at Wayne State University, visit http://www.research.wayne.edu.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2011-11/wsu--wsc110211.php

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Jackson doctor won't testify as trial nears close (Reuters)

LOS ANGELES (Reuters) ? Michael Jackson's doctor on Tuesday declined to testify as both the prosecution and defense rested their cases in the trial in which he is charged in the 2009 death of the pop star.

Asked by the judge whether he wanted to take the witness stand in his involuntary manslaughter trial, Dr. Conrad Murray replied: "My decision is that I will not testify in this matter, judge."

Murray had said on Monday he was still undecided about testifying.

His decision means that the only time the jury will have heard from Murray was in a two-hour tape of a police interview he gave two days after Jackson's death in June 2009.

Defense and prosecution lawyers later rested their cases after more than five weeks of evidence and 49 witnesses. The judge set closing arguments for Thursday.

Murray denies involuntary manslaughter, or gross negligence, in the case. He could face up to four years in prison if convicted.

He was caring for Jackson at his Los Angeles mansion when the 50-year-old pop star was found not breathing just a few weeks before a planned series of London comeback concerts. The singer was later ruled to have died from an overdose of the powerful anesthetic propofol, combined with sedatives.

Murray admits giving Jackson a small dose of propofol as a sleep aid. But his attorneys have sought to convince the jury that the singer somehow gave himself an extra dose of the drug, without Murray's knowledge, and thus caused his own death.

Jurors have heard from more than half a dozen doctors, including one called by the defense, who said propofol is normally used to sedate patients for surgery and should not be given in a home setting where there is a lack of back-up personnel and medical equipment.

Propofol expert Dr. Paul White, the defense's last witness, said on Tuesday that it is not always necessary to have all the commonly accepted monitoring equipment on hand. He cited plastic surgery centers as an example.

But rival propofol expert, Dr. Steven Shafer, took a different view.

"If there was such a thing as bedroom-based anesthesia, the standard guidelines would be considered a minimum," Shafer said on Tuesday.

"Because there's no back-up, there's no tolerance for error. If you have an error, you'll have a mortality."

(Reporting by Alex Dobuzinskis; Editing by Jill Serjeant and Will Dunham)

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/nm/20111101/music_nm/us_michaeljackson

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Jesse James to Appear on American Chopper

Before he became known as the guy who cheated on Sandra Bullock left and right with Michelle McGee and other skanks, and then as the guy in the on-again, off-again relationship with Kat Von D, Jesse James was best known as a biker.

It's probably good the motorcycle enthusiast is returning to his roots.

Formerly the star of Monster Garage, he'll make a return to TV with an appearance on the Discovery Channel's motorcycle series American Chopper.

The 42-year-old James will be competing against the show's father and son stars, Paul Teutul Sr. and Paul Teutul Jr., for the title of Master Bike Builder.

Can he do it? Will you tune in to find out?

The special is scheduled to air on December 5 and 6, with the first night featuring a lot of pre-taped footage of the trio building their respective bikes.

Viewers will then be able to vote on the finished products, and the winner will be crowned live in Las Vegas on the second night, according to the report.

Source: http://www.thehollywoodgossip.com/2011/10/jesse-james-to-appear-on-american-chopper/

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[OOC] In Sanity City

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The Pulse: Former Phila. colleagues remember Cain fondly (Philadelphia Inquirer)

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