Wednesday, 13 February 2013

Clinical trial looks to improve pancreatic cancer survival rates

Special to the Journal

AUGUSTA, Ga.?Researchers at Georgia Regents University Cancer Center are investigating a new avenue of treatment to help boost poor pancreatic cancer survival rates.

The treatment combines a standard chemotherapy drug with a monoclonal antibody that may help the immune system fight pancreatic cancer.

Dr. Samir N. Khleif

Every year, nearly 44,000 patients are diagnosed with pancreatic cancer and more than 37,000 die from the disease?including well-known figures such as Patrick Swayze, Margaret Mead and Luciano Pavarotti.

Despite increased public attention, the disease remains one of the deadliest forms of cancer because it tends to be symptom-free at its earliest?and most treatable?stages. Overall five-year survival rates are a dismal 5.6 percent.

Patients treated with surgery typically see their cancers recur within about seven months. Coupling surgery with the chemotherapy drug Gemcitabine in eligible patients extends disease-free survival to a little over 13 months. Now, researchers are turning to combination therapies to improve these rates, coupling chemotherapy with drugs that enhance the immune system?s ability to fight cancer.

?One of the reasons cancer can be so difficult to treat is the fact that the immune system often doesn?t recognize tumor cells as cancer, or the tumors themselves express substances to suppress the immune system,? said GRU Cancer Center Director Samir N. Khleif. ?Immunotherapy is considered to be an important approach since it targets those specific substances in order to establish a more effective response against cancer.?

Promise has already been shown in monoclonal antibodies that fight cancer?s ability to evade the immune system, said Khleif, who is the principal investigator on a pilot study combining Gemcitabine with a monoclonal antibody called CT-011 in certain pancreatic cancer patients who have been treated with surgery.

In animal models, CT-011 has been shown to inhibit tumor growth and extend survival in melanoma, lung cancer, fibrosarcoma, leukemia/lymphoma and colorectal cancer. It works by shutting down cell production of a protein called PD1 and its related proteins. PD1, also known as programmed death 1, triggers immune suppression in cancer.

?One of the main causes for immune suppression in pancreatic cancer and other cancers is the elevated expression of these proteins in tumors and surrounding cells,? said Khleif. ?This is why our cancer center is taking a leading role in advancing clinical trials examining the effectiveness of combination therapies?which are increasingly being recognized as a promising new avenue of treatment for cancer.?

The clinical trial plans to enroll 32 patients with pancreatic cancer who have undergone surgical resection. For more information or to see if you may be eligible, visit georgiahealth.edu/cancer/trials or call 888-658-0422.

Source: http://thealbanyjournal.com/2013/02/clinical-trial-looks-to-improve-pancreatic-cancer-survival-rates/

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Tuesday, 12 February 2013

APNewsBreak: Flaws found in US missile shield

FILE - In this Friday, May 4, 2012 file photo, a Russian military officer is on duty in the main control center of a radar station at the missile defense facility in Sofrino, 50 km (31 miles) northeast of Moscow. Secret U.S. Defense Department studies have cast doubt on whether a multibillion dollar missile defense system planned for Europe will ever be able to protect the United States from Iranian missiles as intended, congressional investigators say. (AP Photo/Mikhail Metzel, File)

FILE - In this Friday, May 4, 2012 file photo, a Russian military officer is on duty in the main control center of a radar station at the missile defense facility in Sofrino, 50 km (31 miles) northeast of Moscow. Secret U.S. Defense Department studies have cast doubt on whether a multibillion dollar missile defense system planned for Europe will ever be able to protect the United States from Iranian missiles as intended, congressional investigators say. (AP Photo/Mikhail Metzel, File)

Sailors man the rails aboard the guided -missile destroyer USS Barry as the ship depart the Norfolk Naval Station Thursday morning, Feb. 7, 2013 for a 6-month deployment. The USS Barry has deployed to Europe to protect U.S. allies from ballistic missiles. (AP Photo/TheVirginian-Pilot,Bill Tiernan) MAGS OUT

Sailors man the rails aboard the guided -missile destroyer USS Barry as the ship departs the Norfolk Naval Station Thursday morning, Feb. 7, 2013 for a 6-month deployment. The USS Barry has deployed to Europe to protect U.S. allies from ballistic missiles. (AP Photo/TheVirginian-Pilot,Bill Tiernan) MAGS OUT

(AP) ? Secret Defense Department studies cast doubt on whether a multibillion-dollar missile defense system planned for Europe can ever protect the U.S. from Iranian missiles as intended, congressional investigators say.

Military officials say they believe they can overcome the problems and are moving forward with plans. But proposed fixes could prove difficult. One possibility has been ruled out as technically unfeasible. A second, relocating missile interceptors planned for Poland and possibly Romania to ships on the North Sea, could be diplomatically troublesome.

The studies are the latest to highlight serious problems for a plan that has been criticized on several fronts.

Republicans claim it was developed hastily in an attempt to appease Russia, which had opposed an earlier system. But Russia is also critical of the plan, which it believes is really intended to counter its missiles. A series of governmental and scientific reports has raised questions about whether it would ever work as planned.

At a time that the military faces giant budget cuts, the studies could lead Congress to reconsider whether it is worthwhile to spend billions for a system that may not fulfill its original goals.

The classified studies were summarized in a briefing for lawmakers by the Government Accountability Office, Congress' nonpartisan investigative and auditing arm, which is preparing a report. The GAO briefing, which was not classified, was obtained by The Associated Press.

Military officials declined repeated requests to discuss the studies on the record, noting they were classified. Even speaking on condition of anonymity, officials declined to say whether the GAO accurately had reported its conclusions. But the briefing had been reviewed by several Defense Department officials and the revisions they requested were incorporated. There was no indication they had objected to how the studies had been described.

The officials who spoke to the AP emphasized that the interceptor intended to protect the United States is in the early stages of development and its capabilities are not known. They said that the U.S. is already protected by other missile defense systems. Even if European-based interceptors are unable to directly defend the United States, they say they would protect not only European allies and U.S. troops stationed on the continent, but also U.S. radars there that are necessary for all U.S. missile defense plans.

Missile defense has been a contentious issue since President George W. Bush sought to base long-range interceptors in Central Europe to stop missiles from Iran. Some Democrats criticized the plans, saying they were rushed and based on unproven technology. Russia believed the program was aimed at countering its missiles and undermining its nuclear deterrent.

It might seem logical for the U.S. to want to have a defense against Russian missiles, but it's not that simple.

A new missile defense system aimed at Russia could undermine the balance between the nuclear powers, leading Moscow to add to its arsenal and build up its own defenses. It would undermine prospects for further cuts in nuclear weapons, which are a priority for President Barack Obama, and could hurt U.S.-Russian cooperation on other issues of international importance.

Obama reworked the plans soon after taking office in 2009, saying the threat from long-range Iranian missiles was years off. His plans called for slower interceptors that could address Iran's medium-range missiles. The interceptors would be upgraded gradually over four phases, culminating early next decade with those intended to protect both Europe and the United States.

The plans have gained momentum in Europe with the signing of basing agreements in Poland, Romania and Turkey, as well as backing by NATO.

Russia initially welcomed the plan, but now strongly opposes it, especially the interceptors in the final stage. Russia fears those interceptors could catch its intercontinental missiles launched at the U.S.

It is that fourth stage that is now at issue.

The GAO investigators said that the classified reports by the Missile Defense Agency concluded that Romania was a poor location for an interceptor to protect the U.S. It said the Polish site would work only if the U.S. developed capabilities to launch interceptors while an Iranian missile was in its short initial phase of powered flight.

But the administration is not pursuing that capability because it does not believe it is feasible, according to one senior defense official.

The military has considered deploying interceptors on ships, but the Navy has safety concerns that have not yet been resolved. The suggestion of attempting intercepts from ships on the North Sea probably would aggravate tensions with Russia. That could put it right in the path that some Russian ICBMs would use, further reinforcing Russia's belief that it, not Iran, is the target of the system.

The GAO investigators also took the administration to task for not conducting studies earlier that could have revealed the problems. Reports by the GAO and scientific bodies advising the government have raised other concerns about the missile shield, citing production glitches, cost overruns, problems with radars and sensors that cannot distinguish between warheads and other objects.

One report by the National Academy of Sciences recommended canceling the fourth phase of the system and deploying the interceptors to the East Coast.

The GAO study was requested by Rep. Michael Turner, R-Ohio, who until recently led a panel that oversees missile defense. He said he is concerned that the interceptor in development might be useless in protecting the United States.

"This report really confirms what I have said all along: that this was a hurried proposal by the president," he said.

___

Online:

Missile Defense Agency: http://www.mda.mil/system/system.html

___

Follow Desmond Butler on Twitter: http://twitter.com/desmondbutler

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-02-09-US-Europe-Missile%20Defense/id-d119471687de413bb8d85c44687b0f16

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Utah football: Utes add Dennis Erickson to coaching staff

College football ? Veteran college and NFL head coach will become co-offensive coordinator

It?s offensive coordinator mentor ?Take 2,? for the Utes.

Utah announced Monday that former Arizona State coach Dennis Erickson has been hired as Utah?s co-offensive coordinator.

?

Utah?s offense under Whittingham

Scoring Offense

Year Average National Rank

2012 26.7 73rd

2011 25.0 74th

2010 33.1 23rd

2009 29.9 34th

2008 36.9 15th

2007 26.2 68th

2006 27.9 33rd

2005 30.0 36th

Total Offense

Year Average National Rank

2012 324.42 105th

2011 310.9 109th

2010 389.0 57th

2009 389.5 54th

2008 400.9 35th

2007 369.9 79th

2006 368.4 41st

2005 473.0 12th

Erickson, who went 179-96-1 in 23 seasons as a head coach and won two national championships, was in town a week ago for an interview. The 65-year-old Erickson returned to Phoenix Tuesday night and had a hip replacement Wednesday. He will begin his new duties on Feb. 19, according to the school?s release.

"Dennis Erickson brings a wealth of knowledge and coaching experience to our program," Utah coach Kyle Whittingham said in a statement. "He has been labeled as one of the architects of the spread and we are looking forward to the impact he will have on our offense. Coach Erickson also has recruiting connections across the country which should benefit us on that front as well."

The hiring is similar to the one the Utes made in January of 2011 when Norm Chow was brought in as offensive coordinator with the hopes his experience and offensive knowledge would help not only Utah?s players but young coaching staff.

His departure to become Hawaii?s head coach at the end of the 2011 season led to the promotion of quarterbacks coach Brian Johnson to the offensive coordinator?s position while Aaron Roderick was named passing game coordinator.

Johnson, who turns 26-years-old on Saturday, will share the coordinating duties with Erickson.

Erickson won national titles in 1989 and 1991 as the coach at Miami and was the 2000 Sporting News National Coach of the Year while at Oregon State.

He has been the head coach at six universities, including Pac-12 schools Washington State, Oregon State and Arizona State.

Erickson most recently coached at Arizona State from 2007-11 where he went 10-3 in his first season, but failed to win more than six games in his final four years. He was fired on Nov. 28, 2011 with a final record of 6-7.

story continues below

Erickson?s aggressive offensive style might be just what the Utes? offense needs as it has struggled in recent years to be as dynamic as Whittingham wants it to be.

The Utes ranked at or near the bottom of the Pac-12 in the major offensive categories in 2012, averaging just 26.7 points last year and 324.4 yards of offense.

Copyright 2013 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/utes/55808433-89/coach-erickson-offensive-coordinator.html.csp

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Monday, 11 February 2013

US to have unprecedented voice in electing new pope

Franco Origlia / Getty Images, file

Wisconsin native James Harvey, right, was among six new cardinals installed during a ceremony on Nov. 24.

By John Newland and Claudio Lavanga, NBC News

Updated at 12:51 p.m. ET: When the next Papal Conclave meets behind closed doors to replace the retiring Pope Benedict XVI, the United States will have an unprecedented voice in the process.

Eleven cardinal electors, almost 10 percent of the conclave, will be Americans -- the largest share the country has ever had, even though it has historically had a large Catholic population.

The retiring pope gets credit for the greater influence of the U.S.


Last year, he named three new American cardinals, increasing the U.S. total to 19. Only 11 will be electors because in order to vote in the papal election, the cardinals must be under 80 when the pope being replaced dies or leaves his seat.

With 11 votes, the U.S. is now the second-largest bloc, behind only Italy, which has 28 electors, according to the Holy See press office at the Vatican. Germany is third, with six.?The new pontiff is expected to be elected by the end of March, according to Vatican officials.

The archbishop of New York, Cardinal Timothy Dolan, explains the "mixed emotions" he feels about the news that Pope Benedict XVI will resign on February 28, saying he feels a "special bond" with the pope.

Cardinal?Timothy Dolan, the archbishop of New York who was elevated to cardinal last year,?is considered a longshot candidate to succeed the pope.

When asked about the qualities necessary for the next pope, Dolan told TODAY that "a good place to start would be to look at Pope Benedict."

He added: "There's a learning, a savviness about the world, there's a theological depth, there's an unquestionably personal piety and holiness, there's a linguistic talent, there's a knowledge of the church universal."

When asked whether he would be allowed to vote for himself, Dolan laughed. "Crazy people cannot enter the conclave," he joked.

The shift in power toward the U.S. ?reflects the vitality of the Catholic Church in the United States,?? John Paul II biographer George Weigel said in November.

"But I don?t think it likely that any American will be elected pope for as long as the United States remains the world?s pre-eminent power," he added.

Alessandro Speciale, Vatican correspondent at Religious News Service, echoed Weigel?s opinion, adding that ?coming from the world?s only superpower could still be seen as a negative factor in a global church.?

What the increasing U.S. presence among the cardinal electors might mean is that Benedict XVI was very much aware that Catholicism is no longer a predominantly European religion.

Javier Barbancho / AFP - Getty Images

Joseph Ratzinger became Pope Benedict XVI in 2005. Look back at his life from childhood through his papacy.

The U.S. has as many as 78 million Catholics, according to the Center for Applied Research in the Apostolate at Georgetown University. For comparison?s sake, Italy, despite having the largest share of electors and being primarily Catholic, has a total population of fewer than 61 million residents, according to World Bank estimates from 2011.

"It remains to be seen whether this numerical weight will actually translate into influence at the conclave," Speciale said in November. "Though national links are powerful, many other factors ... play into the secret voting at the Sistine Chapel."

Some experts have suggested that the next pope might be from Latin America.

Reuters noted Monday that?Latin America now "represents 42 percent of the world's 1.2 billion-strong Catholic population, the largest single block in the Church, compared to 25 percent in its European heartland."

Archbishop Gerhard Mueller, who now holds the pope's old post as head of the Congregation for the Doctrine of the Faith, is among the senior Vatican officials to suggest that it might be Latin America's turn.

"I know a lot of bishops and cardinals from Latin America who could take responsibility for the universal Church," he told?Duesseldorf's Rheinische Post newspaper in December.

?

The 85-year-old pope says he no longer has the strength to carry out his duties, announcing that he will resign effective February 28. NBC's Claudio Lavanga reports from Rome.

Related:?

Pope Benedict XVI to step aside on Feb. 28

'Heavy heart but complete understanding': Pope's resignation stuns church leadership

From prisoner of war to pontiff: A timeline of Pope Benedict XVI's life

Source: http://worldnews.nbcnews.com/_news/2013/02/11/16926292-us-will-have-unprecedented-voice-in-electing-new-pope?lite

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Attack on Fed Exposes Weak Patch Maintenance

While many Americans watched the wrap-up of the Super Bowl Feb. 3, the band of hackers called Anonymous broke into a Web-facing server at the Federal Reserve and pilfered a list of some 4000 people who work in the banking industry -- many of them ranking executives at banks and credit unions. Later in the week, the Fed acknowledged the break-in.

Source: http://ectnews.com.feedsportal.com/c/34520/f/632000/s/287387ac/l/0L0Stechnewsworld0N0Crsstory0C772770Bhtml/story01.htm

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Scientists confirm original tetrahedral model of molecular structure of water

Feb. 11, 2013 ? Researchers at Johannes Gutenberg University Mainz (JGU) have confirmed the original model of the molecular structure of water and have thus made it possible to resolve a long-standing scientific controversy about the structure of liquid water. The tetrahedral model was first postulated nearly 100 years ago and it assumes that every water molecule forms a so-called hydrogen bond with four adjacent molecules. This concept was almost toppled in 2004 when an international research group announced that it had experimentally established that water molecules form bonds only with two other molecules.

"The quality of the results was excellent but they merely represent a snapshot of the situation," explained Professor Dr. Thomas K?hne. He has demonstrated the fallacy of the 'double bonding' theory using computer simulations based on new types of combinations of two computational methods recently developed by his group.

Some very special and unique features of water, such as its liquid aggregate state and high boiling point, are attributable to the effect of the hydrogen bonds between the water molecules. The H bonds are formed due to the different charges carried by the oxygen and hydrogen atoms that make up water molecules and the resultant dipolar structure. The traditional, generally accepted view was that water had a tetrahedral structure at room temperature, so that on average each water molecule would be linked with four adjacent molecules via two donor and two acceptor bonds. "In our theoretical approach, the median result we observed over time was always for quadruple bonding," said K?hne. Thanks to the new simulations, he and his colleague Dr. Rhustam Khaliullin have now been able to confirm the old model and also supply an explanation for why double bonding was observed in 2004. According to K?hne, the result was not indicative of double bonding "but of instantaneous asymmetrical fluctuation" only.

There is thus significant asymmetry in the four H bonds of the tetrahedral model because of the different energy of the contacts. This asymmetry is the result of temporary disruptions to the hydrogen bond network, which take the form of extremely short term fluctuations occurring on a timescale of 100 to 200 femtoseconds. These fluctuations mean that one of the two donor or acceptor bonds is temporarily much stronger than the other. But these fluctuations precisely cancel each other out so that, on average over time, the tetrahedral structure is retained.

The results reported in 2004 using x-ray absorption spectroscopy were obtained using water molecules with high levels of momentary asymmetry, which is why essentially only two strong hydrogen bonds were observed in an otherwise tetrahedral structure. "Our findings have important implications as they help reconcile the symmetric and asymmetric views on the structure of water," write the scientists in an article published in Nature Communications. The results may also be relevant to research into molecular and biological systems in aqueous solutions and provide insight into protein folding, for example.

The work of Thomas K?hne's group was undertaken within an interdisciplinary joint project and was funded by the Research Unit Center for Computational Sciences at Johannes Gutenberg University Mainz.

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The above story is reprinted from materials provided by Universit?t Mainz.

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Journal Reference:

  1. Thomas D. K?hne, Rustam Z. Khaliullin. Electronic signature of the instantaneous asymmetry in the first coordination shell of liquid water. Nature Communications, 2013; 4: 1450 DOI: 10.1038/ncomms2459

Note: If no author is given, the source is cited instead.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/Slp1ezuSa8I/130211202018.htm

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Lakes of the Four Seasons Ranch Land For Sale | oicenapura

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Source: http://oicenapura.blogspot.com/2013/02/lakes-of-four-seasons-ranch-land-for.html

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